An innovative approach to reach “hard-to-access cancers” in the abdomen — Intraperitoneal Chemotherapy

This therapy targets peritoneal dissemination, a condition in which cancer cells spread across the peritoneum “like seeds.” By directly administering anticancer drugs into the abdominal cavity, it enables a high concentration of medication to act locally where conventional intravenous chemotherapy cannot reach effectively.

A catheter port is placed in the patient’s abdomen, allowing anticancer agents to be delivered directly into the abdominal cavity for more targeted treatment.

Benefits of Intraperitoneal Chemotherapy

High drug concentration directly targets cancer

In intraperitoneal chemotherapy, anticancer drugs spread throughout the entire abdominal cavity and come into direct contact with peritoneal metastases while maintaining a high concentration. In general, the greater the amount and the longer the exposure of cancer cells to a high drug concentration, the more effective the treatment becomes.

Long retention of anticancer agents

Paclitaxel, the anticancer agent commonly used in intraperitoneal chemotherapy, remains in the abdominal cavity much longer than drugs such as cisplatin or mitomycin after administration, ensuring sustained therapeutic effects.

Reduced systemic side effects

Because paclitaxel administered into the abdominal cavity is absorbed slowly and gradually, systemic side effects such as nausea or loss of appetite are less likely to occur.

Risks and Side Effects

There is a possibility of infection or blockage at the port insertion site, as well as intestinal obstruction related to the catheter. Although intestinal perforation or peritonitis associated with intraperitoneal administration has not been reported to date, these remain potential risks that must be carefully monitored.

Treatment Process

• STEP1Placement of the Intraperitoneal Port

  A port is implanted beneath the abdominal skin to allow direct administration of anticancer drugs. The procedure is performed under general anesthesia, typically in conjunction with a diagnostic laparoscopy by Dr. Hiyama at an affiliated hospital.

• STEP2Saline Infusion

  A needle is inserted into the port, and 500 mL of saline solution is slowly infused over approximately one hour.

• STEP3Paclitaxel Administration

  Paclitaxel, dissolved in 500 mL of saline, is then infused through the same port over the course of one hour.

Intraperitoneal Chemotherapy Fee

Intraperitoneal chemotherapy is a private medical treatment and is not covered by public insurance.

The above prices are approximate and may vary depending on the dosage, number of sessions, and additional infusion medications used.

This therapy is generally performed in combination with other treatments. A detailed estimate including combined therapy costs will be provided prior to treatment.

Note: The displayed rates apply to members residing in Japan who hold a health insurance card (My Number Card).

Those without these documents will be charged the non-member rate.

Intraperitoneal chemotherapy offers the advantage of delivering high drug concentrations directly to the target area while potentially reducing systemic side effects.

If you are considering additional treatment options or seeking a second opinion, please feel free to contact us for further consultation.