Stem Cell Supernatant Therapy
Stem cell supernatant therapyExpected benefits.
Growth factors, cytokines and other bioactive substances secreted by stem cells act directly on stem cells and cells with high regenerative capacity in the body to promote tissue regeneration.
■Tissue and nerve repair action
■Anti-inflammatory effect
■antioxidant action
■Trauma healing effect
■Immunomodulatory effects
■Active oxygen removal
■Vascular regeneration and angiogenesis
■cosmetic action
Stem Cell Supernatant Therapy Provided at Our Clinic
At our clinic, we offer three types of stem cell supernatant therapy: "bone marrow-derived," "umbilical cord-derived," and "adipose-derived."
All of these treatments use "Secretome," a high-quality stem cell supernatant produced by Celestar.
Celestar's products are Xeno-Free, meaning they do not contain bovine-derived serum (FBS) and instead use human platelet lysate in accordance with FDA guidelines.
Additionally, only products that pass strict screening tests for donors, culturing, manufacturing processes, and final product inspections are shipped.
■ Bone Marrow-Derived Stem Cell Supernatant Therapy
Exceptional Exosome Content
Bone marrow contains hematopoietic stem cells and mesenchymal stem cells (MSCs), with MSCs playing a crucial role in tissue repair and immune modulation. The supernatant derived from bone marrow stem cells has strong anti-inflammatory, immune-regulating, and tissue-regenerating properties, making it particularly suitable for the treatment of joint diseases, neurological disorders, and autoimmune diseases.
■ Umbilical Cord-Derived Stem Cell Supernatant Therapy
High Growth Factor and Cytokine Content
“Umbilical Cord-Derived Stem Cell Supernatant Therapy” involves culturing stem cells extracted from the human umbilical cord and obtaining the supernatant from the culture medium. The umbilical cord, also known as the birth cord, contains mesenchymal stem cells (MSCs) that have gene expression properties closer to embryonic stem (ES) cells—derived from fertilized eggs—than stem cells harvested from adult tissues such as bone marrow or fat.
Additionally, umbilical cord-derived stem cells have a high concentration of cytokines, which contribute to tissue repair, immune suppression, and anti-inflammatory effects. Studies suggest that umbilical cord-derived MSCs provide stronger neuroprotective effects than those from bone marrow or fat, making them a promising option for treating nerve-related disorders.
■ Adipose-Derived Stem Cell Supernatant
Stem Cell Supernatant with High Donor Transparency
Adipose-derived stem cell supernatant has strong anti-inflammatory properties and tissue repair capabilities, making it a promising treatment for joint diseases, aesthetics, and inflammatory conditions.
The adipose-derived stem cell secretome provided by Celaster is produced from the most superior cells, selected through comparative analysis of over 500 samples. These cells are obtained with donor consent from healthy Japanese women in their early 20s (who have not received the COVID-19 vaccine), ensuring clear traceability.
Risks and side effects.
Side effects such as pain at the puncture site, internal bleeding and neuropathy from injections and infusions are rare. Allergic reactions are said to be almost non-existent, but please consult if you have had allergic reactions in the past.
Clinical use of stem cell culture supernatants
Systemic administration by intravenous drip
（１） The culture supernatant fluid is added to a solution such as an intravenous drip and slowly administered intravenously. The wide variety of cytokines contained in the culture supernatant solution is expected to activate cells in damaged areas of the body and improve various ageing phenomena. It does not cure diseases, but improves the damaged environment and promotes the metabolism of damaged cells, thereby providing a preventive effect for a wide range of diseases and a complementary therapy for disease improvement.
（２） One of the characteristics of the effects of 'stem cell culture supernatant fluid' is 'repair of damaged areas'. As it compensates for weakened cell parts, the effects appear differently depending on the method of administration, but the body and skin are improved from the areas that require restoration. Regular treatment is also expected to prevent ageing, treat thinning hair and maintain health.
■ cardiovascular disorder
■ impairment of liver function
■respiratory impairment
■ renal impairment
■ Complications of diabetes mellitus
Intracerebroventricular administration by nasal drip
The active components of the culture supernatant fluid cannot pass through the cerebral blood barrier of the capillaries in the brain in a normal intravenous infusion. Therefore, if there is a brain disease or functional decline due to ageing, it is administered intranasally instead of by intravenous infusion.
■Improvement of memory loss
■ Improvement of various symptoms after stroke
■ Complementing Parkinson's disease
Number of treatments
Although there are individual differences depending on symptoms and other factors, some people feel some effects after the first treatment; many people seem to feel some effects after five to six treatments. Stem cell culture supernatant solution can be administered by intravenous drip, local injection, intra-articular injection or topical therapy, and is thought to exert its effects by activating stem cells in the body, in addition to the action of growth factors, immunomodulatory factors, anti-inflammatory factors and nerve regeneration factors produced by the stem cells, depending on the pathological condition. The effects are thought to occur through the activation of stem cells in the body.
| Types of cytokines | Main effects |
|---|---|
| vascular endothelial growth factor：VEGF | Hair growth, hair growth, ghost vessel suppression |
| epidermal growth factor：EGF and Family | Improvement of spots and dullness, improvement of epidermal metabolism, improvement of wrinkles |
| Hair abduction site growth factors：KGF | Hair regrowth and hair growth effects |
| insulin-like growth factor：IGF | Skin regeneration, improvement of wrinkles, regeneration of tension and elasticity |
| Platelets by Growth Factor：PDGF | Promotes cell division, proliferation and regeneration of damaged tissue |
| transforming growth factor：TGF-β, RGF-α and their Family | Anti-inflammatory, promotes wound healing and cell growth |
| stem cell growth factor：HGF | Tissue regeneration and activation |
| neurotrophic factor | |
| CNTF（ciliary neurotrophic factor） | Promotion of neural stem cell proliferation and activity |
| GDNF（glial cell line-derived neurotrophic factor） | Promotes neuronal differentiation and growth, dopamine uptake |
| NGF（nerve growth factor） | Synthesis and promotion of neurotransmitters, maintenance of nerve cells, repair of damaged cells, recovery of cranial nerve function, prevention of Alzheimer's disease and dementia |
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- 2F Prairie Ginza Bldg. 1-14-4 Ginza, Chuo-ku, Tokyo See Map
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By train
2-minute walk from Ginza 1-chome Station (Exit 10) on the Yurakucho Line
2 minutes walk from Exit A-3 of Takaracho Station on the Toei Asakusa LineBy car
Tokyo Expressway, Shin-Kyobashi 2 min.Parking lot
Shin-Kyobashi Parking Lot 5 min. walk
Mitsui’s Repark Ginza 1-chome No. 8 Parking Lot 6 min. walk
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Open： 10:00 - 19:00
| Open | Mon | Tue | Wed | Thu | Fri | Sat | Sun |
|---|---|---|---|---|---|---|---|
| 10:00 - 19:00 | ● | ● | ● | ● | ● | ● | Closed |